[dbmikus]

Living healthier for longer will not help the healthcare crisis if the tail-end of life has the same health distribution. I think healthspan is a more important first target that lifespan.

It's great to see some targeted support for bio, though! It seems like a harder market division to get into than a pure tech company.

[reasonattlm]

Think about how complex machines fail. Reliability theory is a good tool for this, and has been used to effectively model how aging works, as failure of units in a system of redundant units.

https://doi.org/10.1006/jtbi.2001.2430

You will see that there is no good way to compress the tail end of mortality and consequences resulting from accumulated unrepaired damage. The only cost-effective path is to postpone it indefinitely through periodic repair of that damage.

Aging is damage, and mortality/disability rises with damage. Effective treatments for aging are forms of repair of damage, of which only senolytics presently exist in any form that is available. Once you accept this model, you can start to reason about the effects of various approaches, and everything makes a lot more sense.

[tomjen3]

If people live healthier for longer, then there will be a larger share of healthy people to pay into the pool of sick people, which should help the healthcare crisis.

[killjoywashere]

Don't you dare talk about QALYs in the US! What are you, a democrat? (Sorry, I couldn't suggest you're Russian anymore, since that's apparently synonymous with Republicans. And Yuri Milner, of YC fame).