[blobwalker]

A low baseline is common in bipolar disorder, too. It was (and to a lesser but unfortunate degree, still is) very commonly misdiagnosed as depression because of this. It reacts quite differently to drugs than depression; many anti-depressants pose a high suicide risk when taken by bipolar individuals. While the overall effect during depressive periods (which can last years) in bipolar seems the same, it seems to have a different underlying cause. Normally you wouldn’t get cycling that fast, but AFAIK, there is even less research so far about how psilocybin affects bipolar disorder. I’m not trying to diagnose anyone... just something to think about for anyone who thinks they might be suffering from depression. I think I was misdiagnosed for many years, leading to decades of ineffective treatments.