[Grieverheart]

I had a look at this review on bipolar disorder, https://doi.org/10.1136/bmj.e8508 . According to a study referenced in it, 68 randomized trials where used to determine the effect of different drugs compared to placebo. Again the sample size is low and the statistical significance is also small, unless I'm missing something.

You are correct in saying that we don't actually know how much we know about the brain. But the brain is s much more complex than e.g. planets orbiting the sun. There are many components that can get affected by chemical compounds in the short term, but more importantly in the long term. I agree though that only through testing can we get a better understanding. It is just the way it's currently done that I disagree. I would gladly read some research you think is good and does not have the shortcomings I describe.