My favorite words for stumping everybody are: lynx and eczema. I thought for sure that 'lynx' would get on that list since there is only a "sometimes" vowel and an 'x' in there.
I'm a big fan of words that use w as their only vowel, like crwth, cwm, and pwll. Pwll is especially good because even if they get P and L, most guessers will go through any common vowels they haven't yet tried, and run out of guesses before they even consider W.