I couldn’t find a comprehensive treatment of the broader issue on a quick check- I suspect that the nature of an issue revolving around “what we know vs what we formally know” resists discussion in places like scientific journals. But there’s some overlap with more well-known issues, such as antibiotic development- even though new antibiotics can be patented, the return isn’t enough to stimulate nearly sufficient development (e.g. https://www.pharmaceutical-journal.com/news-and-analysis/fea... .)