[cup-of-tea]

It's actually pretty easy to set up for general use. I do know and use emacs lisp, but I've not really used any at all for org-mode.

It does support "sessions" which allow persistence across the code throughout the document (you could even have multiple sessions), but the wat it's done for Python is quite hacky. It uses an interactive Python shell so you have to write code as if you're using the shell (double returns etc.) There is a better way using ob-ipython, but after spending a long time getting it to work at all I found it not good enough. Using Jupyter kernels is the way to go, I think, but it would be a lot of work to get it working well with org-mode.