| It's ... complicated: "for every 1000 patients treated for a 5-year period, aspirin therapy would be expected to result in 1 excess hemorrhagic stroke compared with a benefit of ≈14 myocardial infarctions prevented in patients at moderate risk for CHD (5% to 10% 5-year risk)" http://stroke.ahajournals.org/content/36/8/1801 "Aspirin has been found to be a safe in patients harboring cerebral aneurysms and clinical studies provide evidence that it may decrease the overall rate of rupture." https://www.ncbi.nlm.nih.gov/pubmed/25967073 "There was an approximately 40% increased risk of all gastrointestinal bleeding with low-dose aspirin in the observational studies reviewed here, a finding very similar to that reported in randomized trials" "The overall risk of intracranial hemorrhage was also increased by approximately 40% with long-term low-dose aspirin, which is also similar to the estimates from randomized trials, although an increase in risk was not consistently reported in all studies." https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973997/ "Aspirin reduced the 6 week risk of recurrent ischaemic stroke by about 60% and disabling or fatal ischaemic stroke by about 70%" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321490/ "aspirin significantly reduced the risk of myocardial infarction among men by 43%" "significantly increased risk of major extracranial bleeding with aspirin [RR 1.54]. The excess risk of bleeds was mostly non-fatal. Perhaps by chance, fatal gastrointestinal (GI) or other fatal extracranial bleeds were lower in the aspirin group versus control [RR 0.48]" "In a meta-analysis of eight trials including 25,570 patients, aspirin use significantly reduced the overall incidence of cancer-related death by 21%" "In the meta-analysis of six trials, an increased risk of extracranial bleeding was observed with low-dose aspirin; however, the analysis of extracranial bleeding stratified by period of follow-up revealed that the risk of extracranial bleeding decreases over time, becoming comparable to that of placebo or no aspirin from 3 years onwards: <3 years" "In this same analysis, fewer cases of fatal bleeding were associated with aspirin use, compared with controls [OR 0.32]" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383813/ |