[masklinn]

> Yes, that's the main reason aspirin isn't recommended more widely. (Stomach and liver harm are the other big reasons.)

Liver is paracetamol — aside from Reye Syndrome[0] — aspirin is metabolised via the kidneys and I believe even overdoses does not overload the kidneys[1], however aspirin inhibits excretion of uric acid which is why it's contra-indicated to people suffering from gout or kidney diseases.

[0] https://en.wikipedia.org/wiki/Reye_syndrome linked to both aspirin and liver toxicity

[1] in fact one part of aspirin overdose protocol is urinary alkalinization: increasing urinary pH from ~5 to ~8 increases renal elimination of salicylate by 10~20x

[Bartweiss]

Ah, thanks. I knew I'd heard of aspirin-liver related crises, but I hadn't realized Reye Syndrome happened outside of normal metabolism!