[eropple]

Sorry, just saw this. I need to split audio to mix and level it for stuff like live-streamed podcasts. So, on top of that, I need to pull video.

Honestly, the best answer is probably to continue using multiple Skype instances. Which is gross. But, y'know.

[exikyut]

It's fine - you actually saw it, which is cool :) some of my other past replies have gone completely unnoticed

I see. I get the impression this is collaborative podcasting with multiple people that have multiple microphones. (I can't figure out why else you'd need multichannel A+V transport.) FWIW, it does sound like Skype is probably your best bet for the time being (unfortunately). It's simple, it works for everyone, etc.