[raindev]

I've tried to use macOS with case sensitive filesystem for some time (before APFS). Works mostly fine but there're applications that break (Steam and Intellij IDEA are the two I remember).

[kiliankoe]

Adobe apps are another known candidate for breakage on case-sensitive filesystems.

[AdamGibbins]

I've no problems with IntelliJ in recent versions. Steam remains broken, I have to run that from a separate volume.