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by spklin
3186 days ago
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Undetectable is the standard of care and is the definition for the treatment "working". Viral load is checked regularly after starting treatment. If it doesn't become undetectable quickly with first line meds, there may be compliance or resistance issues and treatment approach is changed. With current protocols the main reason for treatment failure is mental health/substance abuse interfering with adherence. The studies on transmission are using sero-discordant couples who are not using condoms. The evidence/confidence has been building over time with multiple studies in which no transmissions were observed. http://www.catie.ca/en/catienews/2016-09-06/negligible-risk-... The HPTN 052 randomized study was halted early because the evidence so strongly favored the treatment arm. In the PARTNER observational study, no transmissions were observed in the study at all. The evidence is very strong. |
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