[joshuahedlund]

Can someone knowledgeable provide more details about the "tri-specific" nature of the attack and what effects this might have on the selective resistance of the remaining strains? (e.g. is it something that would take three simultaneous mutations to overcome, thus being much less likely than any resistance that only takes one, due to HIV's incredibly high mutation rate, though those that do achieve all three would still be resistant?)

[otakucode]

I cannot personally do so, but I know who can and almost certainly will. The 'This Week In Virology' podcast. It's run by the head of the Columbia University virology department and a few other respected researchers in the field and is an absolutely phenomenal resource whenever there is news about virology. It doesn't look like they've covered this yet (too new) but I expect it to feature large in their next episode. If you're interested in a real technical dive into the topic, that is the place to go.

http://www.microbe.tv/twiv/

(Related personal anecdote and why I recommend them so highly: I'd been listening to them for awhile, then a research paper came out showing a possible link between Chronic Fatigue Syndrome and XMRV in mice. People online had taken the paper and went crazy with it and some people were finding sources for murine (mouse) cancer drugs and dosing themselves with it in hopes of curing their CFS. They went through the paper and recognized the researcher and lab who wrote it. And noted that the lab had previously published XMRV research. XMRV is apparently remarkably difficult to eliminate contamination from. Basically if a lab has ever worked with it, you have to burn down the lab and build anew if you want to be sure it isn't around. So they advocated skepticism and said wait for independent verification before getting too worked up. A couple months later, the original paper was retracted as the researchers announced no other lab could reproduce their findings and it was down to XMRV contamination of their samples. That is the kind of thing you only get when you're listening to bona fide experts in their field and it blew my mind.

[JCSato]

This is why I love HN. Thanks for the resource!

[aswanson]

Right. There's almost always someone that can do a deep dive on an interesting, esoteric technical topic. No resource on the web like it with this level of diversity and depth.