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I vouch for it based on my personal experience - I suffered from a serious and untreatable autoimmune disorder (of thyroid, not directly of gut), and the only 'treatment' proposed by doctors was to cut out my thyroid and make me dependant on taking thyroid hormones orally for the rest of my life. I refused, did some research on my own, and went on keto. My thyroid bloodwork is back to normal and I have no symptoms. And I feel much 'healthier' and more 'energetic' than before all this as well. I am not proposing keto diet as a magical cure-for-all, but as a possible venue that should be tried before being forced to undergo irreversible surgical procedures for example. P.S. body does not 'switch' the energy source to fat, it increases the production of ketones as result of interrupted Krebs cycle ( https://en.wikipedia.org/wiki/Citric_acid_cycle ) because oxaloacetate gets rerouted for use in gluconeogenesis (creating glucose for brain's needs), because there's not enough glucose in diet. This interruption causes the buildup of the main source for Kreb's cycle, acetyl-COA, which is then converted to acetoacetate (a ketone), which is then also partially converted to acetone and beta-hydroxybutyrate (also ketones). Of these, body uses acetoacetate and beta-hydroxybutyrate as fuel. Body is always able to use them, it's just that there's not enough of them to use if you're not on carb-restricted diet, so body defaults to using glucose as fuel. Like you say, long-term effects of keto are poorly studied, mostly because of two reasons: early keto hype as an effective seizure treatment died out once we got good enough chemical seizure treatments, and there was a lot of money poured into blaming fat intake for negative health effects of increased carb intake from the 50ies (starting with Ancel Keys), and picking up significantly in 70ies. There are animal studies that demonstrate increased longevity of animals on keto diet, similar to calorie restriction and strict veganism. While the calorie restriction and strict veganism most likely work through lowered intake of methionine (an essential aminoacid which functions as START coding block for protein synthesis, meaning that with lowered methionine intake your body creates protein at lowered rate and renews itself more slowly), keto achieves that through effectively tricking the body to go into 'starvation mode' i.e. the mode of using own fat reserves while the actual fat source is the diet. |