[eru]

> Second, you can't really cheat your biology in the long run, because your brain will always compensate for any psychoactive drug you consume.

I don't know, if that's true in general. I know that I can seriously harm myself using lots of stuff --- so why shouldn't the other way be possible as well? (I don't claim that anybody knows how to achieve the positive outcome.)

[carbocation]

I think Alex3917 is right on the money here. Often, the way that you harm yourself is by depriving your body of the drug you were previously consuming.

Theoretically, what you propose could be possible, but would probably involve multidrug therapy with the goal of inhibiting the regulatory pathways that would counteract the drug of choice.