[michalskop]

We (very very small EU NGO) do it. I run an emailing of dozens of thousands emails about once a year - before some elections, we prepare some pre-election tools for people. I use simple php for that, so the setting is actually quite bad with regards to spamfiltering. But we get several percents response rate - people coming to our website and using the tools - the very day I send it, which is very good (and more people later), most of businesses would really like to achieve that, imho.