[CydeWeys]

I would expect prions to be harder to sterilize than bacteria, actually. Prions aren't even alive.

[ciniglio]

They are much harder to sterilize, and autoclaves don't work. Ideally you'd dispose all tools exposed to prions, but if that's infeasible, the CDC recommends an autoclave in a bath of NaOH.

https://www.cdc.gov/prions/cjd/infection-control.html