Sorry, it was a vague attempt to foster discussion about the options of moving out of WSGI without throwing it out completely (I was really ill yesterday and couldn't quite formulate any logic thoughts around it myself).
Have you looked at the options there / if there would be an easy way to bolt on a more async driven framework? Obviously, it doesn't solve the missing framework issue, but maybe there's some clever tricks you can do because uwsgi is allowing you to bend the rules.