Chez Scheme [0] is written using the nanopass framework, and it's regarded as one of the fastest Scheme compilers in existence [1]. Before it was rewritten to use the nanopass system, Chez's compiler was known for its performance in terms of lines of code compiled per second; the rewrite slowed it down a bit, but the quality and performance of generated machine code improved. Andy Keep and Kent Dybvig wrote a paper about the project [2]. I haven't browsed the Chez source, but it's a good way to answer your question.