One mistake per day is enough for the knives to come out. On a big mailing list, think about how many 9's of accuracy you have to have to keep one incident from happening per day. Per week. Per month.
If you asked people, one per month would be a 'working' system, if you catch them on a good day. 'Never' is a very long time.
Will some things filter through this list? Undoubtedly, but I would be surprised if it's a significant percentage. Extremely high-volume lists probably need some more specific care, to be sure.
The auto-reply is probably sent by a desktop email client, which are often offline and/or configured to only check for new email every few minutes. So you'd fail to mark a lot of auto-replies.
If you asked people, one per month would be a 'working' system, if you catch them on a good day. 'Never' is a very long time.