[RandalSchwartz]

dartlang.org is the modern heir-apparent to the Smalltalk language, backed by Google, and gaining a lot of traction.

[teapot7]

Though Smalltalk is quite alive and happy in a niche way. I use pharo.org, but there's also Squeak, VisualWorks and a few others.

There's some good recent work on compiling to JavaScript, which seems to be the universal solvent these days.