[Nullabillity]

NetworkManager is pretty much the default GUI for most distros and DEs, and has built-in support for OpenVPN, PPTP, L2TP, IPsec, SSH, etc... And it also integrates well with the Wifi setup, so you can easily set it up to automatically connect to the VPN when you connect to certain networks.

[joombaga]

Works great with Cisco Anyconnect too. My setup even automatically pulled an RSA token from my stoken config.