[manvsmachine]

I think it would work - essentially, this is the entire premise of the simulation market; the only difference is a lesser emphasis placed on motor skills due to it being an RPG. Mastering Gran Turismo / Forza requires players to learn quite a bit about real-world vehicle dynamics, for example. The caveat is that, in your example, the cumulative knowledge required to develop the game would be equal to mastery of every in-game class. You would need several teams of expert consultants to create and model scenarios, much like TV shows that deal with medicine, military, forensics, etc. Realistically, it would make a lot more sense to narrow the focus to one or a few domains.