I've never had a mouse where it wasn't a problem. I don't buy uber-quality mouses, so I'm down in the trenches with the vast majority of mouse users with moderate-to-low quality hardware.
I'm also often using a laptop, on linux, and I do the middle-click-simulation (both buttons at once) with two hands, which is really annoying. I suppose I could fix it.
Also I always have my left hand on the keyboard, so for me it's not a problem to ctrl-click.
Ctrl+click doesn't work on a tab, though--have to hit the X.