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> 1200 people is a fairly huge study, 1200 people is a huge, convincing study for a well-executed prospective, interventional study, like a clinical trial. This is a cross-sectional retrospective study, using merged data from several different sources. Retrospective, epidemiological studies are notoriously subject to bias, particularly ones like this one. Such retrospective studies are good for forming hypotheses about diseases in study populations (and often, intervention studies are not feasible), but they are often inadequate for testing these hypotheses. As the study authors say themselves, longitudinal studies are required to really draw strong inferences. I'd have to read the study to be sure, and it's been a long time since I formally studied or worked in epidemiology/biostatistics, but some of the numbers mentioned in this article look fairly unconvincing. For example, this study found very little association between tobacco use and metabolic syndome, which goes against most available evidence. Also, things like having insurance and being married are associated with a significant increase in metabolic syndrome (not sure if this is in line with existing research, but it sounds kind of counterintuitive). |