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by Laforet 3245 days ago
Neither technique will work in the timeframe you specified because gestation time for horses are almost a year long.

On the other hand, one can slowly breed for desirable traits such as speed, endurance or disease resistance in horses, good luck doing that with GM.
1 comments
vbuwivbiu 3245 days ago
The point wasn't how long it would take for the organism to gestate, it was how long it would take for the trait to be introduced into the organism.

We can do that precisely for fluorescence and many other traits with GM today, but good luck trying to breed a fluorescent horse, it could take millions of years if at all.

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Laforet 3245 days ago
There is no reliable or efficient vector to introduce fluoresence to somatic cells in a horse-sized animal, so no, 1 month is still way too short. You seem to have a highly romanticised idea about the capability of GM but it is misguided.

Besides, GFP fluoresence is the proverbial low hanging fruit as it is robustly expressed in many cell types but has very little practical value. Inserting useful traits via GM is often no short cut because they are rarely determined by a single gene.

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vbuwivbiu 3245 days ago
the point isn't about actually growing an adult fluorescent horse, it's about proving the principle in an embryo - which takes days. It's already been done with mice, but I agree it's a simple example.

Your point about multiple genes is a very good one but we have a good understanding of how some gene networks work already and the rest will follow.

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Laforet 3245 days ago
The problem with embyros is that they can be inject with any DNA for a trasient positive result but these may well be discarded or inactivated during development. The recently debuked STAP cells used injected embyros as evidence and it turned out to be either a fluke or outright fraud. To prove the concept you really need a stable F1 generation to illustrate that the trait can be passed down in the germline.

I'd say that our ability to interact with the genome is still rather crude, else we'd have already cured cancer by now - we already have a pretty good understanding of the cellular biology of cancer but it only helps us so much.

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