[icanhackit]

> At any rate the glucose uptake is generally lower with fruits, even if juiced

Fruit is typically a source of fructose, which uses a different metabolic pathway to glucose. Fructose is processed via the liver and converted into glycogen for energy storage.

That said, juice is definitely worse than whole fruit as you typically use several serves of fruit for a single serve of juice. Rarely would anyone eat 3-5 whole oranges in a single sitting. The sugars in a serve of fruit are also locked in a cellulose matrix (fibre) which limits the rate of release, whereas juice is effectively predigested food lacking the slow-release mechanism of the fibre. You're going to be loading your liver with an unnatural amount of sugar, not unlike pouring a jar of honey down your gullet.

It's a reason you should avoid mixing strong alcohol and juice or fructose-heavy soft drinks - you're hitting your liver with both barrels. Add paracetamol to the mix, which in even relatively low doses is toxic to the liver, to cure the morning headache and you're going to feel very unwell.

[colechristensen]

>Fruit is typically a source of fructose

The ratio of glucose to fructose in HFCS, honey, and most fruits is about the same. Some fruits have more glucose than fructose, some have less, but the ratio for almost all of them is less than 2:1.