[chillwaves]

> Antidepressants are a unique group of drugs because the dosage is highly dependent on each person's unique brain chemistry and a huge part of a good psychiatrist's job is working with their patients to find the right dosage and combination.

How does one accomplish this absent trial and error?

This fact undermines the entirety of your argument.

"Best guess" is exactly what they do.

[civilitty]

You do know what "unique" means in this context, right? Hint: it means that antidepressants are the exception to my argument because psychopharmacology is so much more dependent on genetic/environmental factors than the rest of the pharmacological field that we cannot draw conclusions on the effectiveness of dosages pre-treatment without spending 100-1000x more time and money on the clinical trials than we do now.

Please take your clearly ignorant bias and anti-pharma prejudice somewhere else - you have no idea what you're talking about.

[AstralStorm]

It is not a guess. It is statistics. Typically, the dose is either effective or partially effective and often on the smaller side as Phase 3 also looks at side effects.