Unlike with Python and similar single-threaded languages you can actually avoid a lot of the complexity of having async everywhere by using the CpuPool reactor for Rust futures.
I imagine Rocket, when it gets its async support, will have the ability to use callbacks to create fully async routes, but the halfway compromise until then will be to have async-dispatched routes that are themselves blocking to a very large threadpool. As long as you have enough generated threads to rarely get all of them stuck in blocking IO you get all the benefits of concurrency without having to callback every IO operation in a route handler.