Glucose is used as fuel, whereas fructose doesn't have a direct pathway to be used as fuel, it must first be stored as fat.
You then have to have an absence of glucose in your body before you may metabolize your body fat. This doesn't happen often for most people, hence, the obesity epidemic from overconsumption of sugar.
That's the short version. The long, detailed version is available from YouTube, search for Dr. Robert Lustig's videos.