[asnyder]

Although you're a Python hacker, you may want to save yourself some time and use NOLOH (http://www.noloh.com). It handles most of the aspects of development that usually distract you and let you focus on your core application. It features a lightweight and on-demand core that offers cross-browser compatibility, automatic AJAX, search-engine-friendly, numerous syntactic features to make developing in it a joy, and much much more.

You can read more about it the website, user blogs, or in this month's php|architect magazine cover story http://www.phparch.com/magazine/2010/may/.

Note that if you're really interested you can join us in our #noloh IRC room and someone can help you put together a prototype in relative short order.

Disclaimer: I'm a co-founder of NOLOH.