[jm2721]

So, for your first question, no, we didn't evolve for the food we need to survive to cause inflammation. In the past, ancient humans had no diabetes or cancer, and ate mostly protein, fats (saturated and monounsaturated), high fiber vegetables, and roughly a 1:1 ratio of omega-6 to omega-3 fatty acids. So it seems more likely that our relatively recent addition of sugar, vegetable oils and highly refined carbohydrates (lacking any fiber content) has something to do with that.

I think your second question is on the money. CR seems like a red herring in this case, because it's likely that those who eat less will also eat less processed foods, less sugars, and more fibrous vegetables or filling fats that would help them actually keep their calorie intake low while still feeling satiated. In the study with the Rhesus monkeys, it said that the ones that weren't on calorie restriction were diabetic or pre-diabetic. Monkeys in the wild don't really get diabetes, in the same way that our human ancestors never got diabetes, so what were they feeding these monkeys? I looked at some of the source studies backing this bbc article. The report from the Nature magazine(https://www.nature.com/articles/ncomms14063) actually says that the University of Wisconsin study 'contained a significantly higher amount of sucrose compared to the NIA diet' (https://www.nia.nih.gov/newsroom/announcements/2017/01/calor...) and that the other study, the one with a diet of varied protein sources, actually did not see any health benefits in the CR monkeys. I wonder, if you fed the UW monkeys a diet low in sucrose and other easily digestible carbohydrates in order to keep their blood glucose and inflammation extremely low, would there be a big difference in the health of the CR monkeys and the others? If the NIA study is any indication, probably not.

[fibbery]

"In the past, ancient humans had no diabetes or cancer"

Do you have a source for this?