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by tuxidomasx 3290 days ago
Research into the neurotoxicity would be very extremely beneficial. The usual advice goes: "You need to protect your serotonin receptors from damage. Antioxidants like Alpha Lipoic Acid are great for this, but in a pinch, a dose of Vitamin C does the trick as well. Hence the advice to drink OJ with your molly."

However, if there was a way to completely prevent damage to the brain and eliminate tolerance, I think many many people would do MDMA every day.
2 comments
anythingnonidin 3290 days ago
To your first point: Yes, I wish we knew more.

To your second point: Quite a timely comment!

I released the results of a ~660 person study on MDMA tolerance/'loss of magic' this morning - as far as I'm aware, this is the first study of this kind.

https://rollsafe.org/mdma-magic/

If you have constructive criticism, that's always appreciated, or if you just like it and find it useful, that's nice too.

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tuxidomasx 3290 days ago
Very cool study on the loss of magic. There has always been anecdotal advice floating around about how to regain the 'magic', but it's good to have some empirical evidence on what actually works.

One of the odd factors that I've heard of but didn't see listed was the "someone new" factor. It maybe somewhat related to the "close friend" factor. Basically, some people claim to regain some magic if you do it with someone you just recently met or reconnected with who has a low tolerance (as opposed to doing it with someone you're already familiar with). Maybe its the empathy combined with the pleasure of making a new friend...

I've heard it makes a difference... but nothing beats supplements and tolerance breaks IMO. lol

We definitely need more studies like this-- there's still so much we don't know about MDMA.

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anythingnonidin 3290 days ago
Thanks for the kind words.

Very good point on the someone new factor. I'll look into that in future studies.

Agreed on the desire for more research!

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cjak 3290 days ago
> I think many many people would do MDMA every day.

It's generally accepted that tolerance to MDMA builds up, leading to a loss of 'magic'.

For example: https://www.ncbi.nlm.nih.gov/pubmed/15671132

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paulcole 3290 days ago
Did you even read the beginning of the sentence you partially quoted?
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