[alakin]

There is a genotype called ApoeE-e4/e4 which increases risk by 11x. https://snpedia.com/index.php/APOE

Interestingly the only differences between Apoe4 and a neutral, very common variant called ApoE3 is one amino acid at position 112. The small variance appears to account for most of the negative effect of the ApoE4 genotype. https://www.ncbi.nlm.nih.gov/pubmed/28533891