Yes, React will be baked into the browser, wasm will be supported widely and everyone will write JS in their favorite language. Not to mention JS will have threads.
I've been going through the challenges and projects at freeCodeCamp to shore up my JS skills. I had been using React and started to focus on the D3.js projects. Started a new project with React and now I'm being told that React.createClass is being deprecated in v16. JS the language is getting better and more powerful. The frameworks and the libraries are a moving target.