[problems]

I believe Java and C# enforce specific byte orders to get around this issue, so I doubt you'll see a problem there unless interacting with C++ libraries.

[MichaelGG]

Not if you're converting bytes into integers, for instance. E.g. https://msdn.microsoft.com/en-us/library/system.bitconverter... - it's arch specific.

[problems]

Interesting, similar functions in the Java world are always big endian:

http://docs.oracle.com/javase/6/docs/api/java/math/BigIntege...

Seems like a rather poor decision on Microsoft's part. Fortunately rather few things interact with data this way anyways, most serialization formats are text based or include endian information.