[pietrasagh]

Is there any way to isolate wine and limit write permisions to user files? I only found this https://askubuntu.com/questions/327223/how-to-isolate-wine#3...

[basemi]

I would try firejail

    https://firejail.wordpress.com/

[mike-cardwell]

Same way you isolate any program on Linux. SELinux, AppArmor, or running as a dedicated user.

[edit] I suppose there are containers nowadays too.

[pmlnr]

containers still need apparmor/selinux to be secure; a container is just a packaging method without those.