[Baeocystin]

I'm dismissing her because she has made no testable claims, and the medical conditions that do cause swelling of the brain are orthogonal to the brain in its healthy state. It does not follow that what is appropriate treatment for a pathology would have a similar effect on a non-swollen brain. This is, quite literally, one of the most common logical fallacies there is. By definition, that makes it an irrational belief.

https://en.wikipedia.org/wiki/Affirming_the_consequent

In addition, there are a vast number of medical cases involving cranial penetration in otherwise healthy adults. Some of them involve the skull only, with no underlying brain trauma. If trepanation has some sort of unsuspected, detectable benefit aside from placebo, it would have been noticed by now. Head trauma is not that uncommon.

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If she wants to explore the potential benefits of trepanation and get it taken seriously, she needs to make testable claims. As she is going uphill against a mountain of pre-existing evidence that holes in the heads of healthy people are not good, she needs to have exceptional evidence, at that. That's how science and knowledge progression works.