[dredmorbius]

Not my field, but:

* Suicide is one terminal option.

* There's a fair history of people who've suffered burnout, or equivalent earlier terms (nervous breakdown, nervous exhaustion, possibly also PTSD and its antecedants -- combat fatigue and shell shock), for the rest of their natural lives.

* Others who've taken multi-year / multi-decadal breaks, or transitioned to other careers or professions.

Again: I suspect considerable variance.