[new299]

I did a quick literature search, but couldn't find anything. It should be easy to answer that question.

There appears to be at least one conserved protein. However there's a lot of scope for different underlying sequences due to synonymous codons.

Depending on how long a fragment you need to target, that could end up being a lot of sequences, and unpractical.

[new299]

It's also possible that HIV could stick introns into the sequence too to avoid CRISPR...