[arcticfox]

You post the classic cautionary comment but reviewing your sources, none of them at all seem relevant:

"Genomic responses in animal models do not mimic themselves in humans" - source? Thalidomide is just a random example of a traditional non-genetic treatment. Specifically the CRISPR mechanism clearly has no precedent of failure, as the Chinese only recently began human trials. There's no precedent of success, but there seems to be no reason to believe it won't work, since it works fine in vivo in other mammals.

And the Lowe link you provided is complaining about in vitro testing; this was in vivo. As far as I can tell, it's exactly what he suggests needs to be done before there's any hype.

If your point is simply that many things have been tried and failed in the past, sure, that's common knowledge. But CRISPR is not a similar approach, there is very little precedent, so IMO optimism is just as warranted as "extreme caution".