Hardly good advice. Tor Browser is specifically built with privacy and security in mind. Using any "mainstream browser" and then expecting to do all those tweaks is not practical advice nor feasible.
As far as using a mainstream browser goes, you'd want to disable a smattering of features to get the most security/anonymity, like plugins and webgl. Any recommendations for a well-thought-out list?
And while I understand the motivation to avoid an exploit magnet, what do you mean by "inferior security design"?