[brut]

From the abstract:

    Intravenously injected quadruplex sgRNAs/saCas9 AAV-DJ/8
    excised HIV-1 proviral DNA and significantly reduced
    viral RNA expression in several organs/tissues of Tg26
    mice. In EcoHIV acutely infected mice, intravenously
    injected quadruplex sgRNAs/saCas9 AAV-DJ/8 reduced
    systemic EcoHIV infection, as determined by live
    bioluminescence imaging.

Can a mod change the title to reflect the findings? The original title is "In Vivo Excision of HIV-1 Provirus by saCas9 and Multiplex Single-Guide RNAs in Animal Models" and should be kept. That way maybe some people wouldn't just reflex-upvote and actually at least read the abstract...

[JCzynski]

That abstract looks completely consistent with the submitted title. I don't see any reason to change it.

[alevskaya]

"Eliminates" is a very loaded term in viral therapy. This paper doesn't show elimination of virus, it shows that the integrated viral genome can be excised in -some- cells by administration of adeno-associated virus harboring the CRISPR system.