I don't know. Probably not. The reason I install with dbus support is to avoid having packages that rely on it not working, should a package ever rely on it (maybe mu4e notifications? idk). Take imagemagick, for example, you can still display images with Emacs without it, but you can't resize them.
I've been using the Emacs that comes from homebrew with the spacemacs plugin (system? Total conversion?). Not a perfect integration when it comes to images but I stick to text and it's been great.