[Achshar]

I have written relatively large (35k lines) project in pure JavaScript (without even jquery) and have never faced any of the issues mentioned by the parent, (Babel helped). I write native first and then run babel to appease my older browser faring users.

The advantages of native are that it's extremely snappy to use and fast to load. Bears smaller memory footprint (have to use angular.js at work and god it's awful) and with newer things like async await, ES16 classes, etc code management is very good. Can't recall the last time I had to take care of a specific browser quirk.

[tps5]

I have no idea what "native" means in this context, care to elaborate?

[Achshar]

I beg your pardon, poor choice of words, native here means plain js. Nothing more.