[emelski]

That's true if you limit yourself to, say, GNU make -- but there are GNU-make-compatible alternatives like Electric Make, part of ElectricAccelerator (http://electric-cloud.com/products/electricaccelerator), that add features like ledger, to trigger rebuilds when compiler flags change; filesystem monitoring for truly accurate dependency detection; and parse avoidance, to avoid reparsing the makefile on every run; as well as a long list of other enhancements.

Disclaimer: I'm the author of TFA and Chief Architect for Electric Make.