> https://www.iifym.com/iifym-calculator/
It's alleged but unknown if the metabolism can be (cumulatively or not) damaged over the long term if the diet is unbalanced to our needs.
And in the human history no population has had a lifestyle as sedentary as we have now. The natural selection adapted to something else.
The mutation of ApoA1 in ApoA1-AS [http://jamanetwork.com/journals/jama/fullarticle/197579 - https://www.ncbi.nlm.nih.gov/snp/28931573] is an example of how the body is adapting to our new diet-lifestyle.