[mosaiclifestyle]

This will hopefully be validated by some of the controlled clinical studies that are just springing up after a decades long moratorium.

I think it's helpful to distinguish between the more recreational, or life-boosting user, and those who might use it to alleviate conditions that would normally warrant psychiatric medications. For the former, you're definitely messing with a stable mind.

For the latter, this is totally a new frontier. This mechanism at least on the surface seems to mimic SSRIs, so presumably tuned properly could be a more holistic replacement, considering LSD's ability to allow people of all conditions to also do some soul searching on a personal level. Similar to how the recommended, accepted treatment is medication + therapy.

[amorphous_hn]

IMO most "stable minds" should be messed with. Stable is relative. Most minds are "stable" in that they are crystallized into arbitrary activity patterns. This is why deep personality change is extremely difficult without psychedelics (you need a transformative experience, psychedelic or otherwise, to change)