[sushid]

Have you already done a 23andMe analysis? If so, you can check out https://promethease.com/. It's exactly what you're looking for as they have constant updates that make it worth your while to rescan every year or so.

[kstrauser]

Promethease is awesome. I uploaded my 23andMe data to it and got back the kind of data I'd been hoping for in the first place.

Fair warning: the UI is very geeky. I think any HN reader should be able to find their way around without trouble, but I wouldn't recommend it to my non-technical friends or family.

[nojvek]

Are you saying 23&Me gives you a file with the full list of chromosome's ACGT data? I've always wanted that.

Also is prometheus and open source analyzer?

[berberous]

23&Me will let you download a text file with the ACGT data, but only for the SNPs that it has. 23&Me does not sequence your full genome, so the SNPs available are a small subset of your DNA.

Prometheus is not open-source (I think), but all it does is read various files with DNA data (like the 23&me export), and match it up with the information in SNPedia (a Wikipedia-like open repository of what we know about certain SNPs), and then exports it to a pretty HTML/JS web report for you that you can download and save.

[lawnchair_larry]

Is it possible to do client side? I'd rather download the db and match it locally than ship my genome to them.

[berberous]

Yes. The author pushes people to the web version since it's more up to date, easier to maintain, etc., but there's a local version, see:

http://snpedia.com/index.php/Promethease/Desktop http://snpedia.com/index.php/Promethease/privacy

[fudged71]

Why would you need to be rescanned? Does your DNA change that often?

[sushid]

Not your DNA, but your Promethease analysis can be redone every year or so as they're constantly adding new analyses.

[fudged71]

Makes sense, thanks!

[adenadel]

They mean rescan with the Promethease software. Our knowledge around genetic variation is evolving rapidly.

[jtmcmc]

IIRC but this is what 23andMe used to do before their FDA smackdown.

[echelon]

Thanks! This is way more interesting than the data 23andMe provides.