[nonbel]

Have you looked into what combination of mutation rates and number of required mutations would be necessary for your model to work? Usually people say it is something like 10^-8 per bp per division and you need to collect 3-6 mutations to get cancer.

[sandworm101]

Isn't cancer predicated on mutations that result in uncontrolled cell growth? I imagine there are a great many mutations that result in cell death or an inability to properly divide. Those mutations wouldn't contribute to cancer risk. So maybe you need 3-6 but only amongst those bits of DNA that actually matter.

[nonbel]

Yes, that is correct. It would only be some "special" combinations of mutations, not just any set.