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by notsosmart
3371 days ago
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When apoptosis fails, it's might be because p53 binds to foxo4 and gets stuck in the nucleus which prevents the p53 from getting to the mitochondria. In the experiment p53 in the paper, p53 unbound from foxo4 in the nuclease and bound to foxo4-dri and successfully flowed down the mitochondria so apoptosis could occur. |
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